We aim to understand the processes underlying cellular targeting and trafficking of the channels and to identify targeting signals within the channel. We will study the role of associated proteins and second messenger systems in regulating M-channel function as well as the interactions between such elements, and we will identify and study the role of the KCNQ ligands in channel function. We also plan to study how the expression of these genes is regulated. Finally, the role of M-channels in neuropathic pain processing warrants deeper investigation and we plan to identify the molecular determinants for the pharmaceutical regulation of these channels, which may help in developing more selective drugs

We expect to gain a much better understanding of the cell biology of these channels and the way in which disease causing mutations affect different processes within a cell. Furthermore, light will be shed on how the behaviour of these channels is modulated by associated proteins, neurotransmitters and second messenger systems, as well as the interactions that occur between these elements. We expect to obtain important insights into the role of KCNQ channels in different human conditions, creating the basis for novel therapies. This aspect will be enhanced by augmenting our understanding of the action of drugs that alter the activity of these channels. Finally, we hope to advance both our understanding of the transcriptional control of the genes encoding these proteins.

The potential applications that might arise from this project involve the possible therapeutic benefits to treat the diseases that arise due to mutations in these genes as well as in neuropathic pain. Furthermore, it is likely that the insights into the way that these channels are modulated will also be applicable to other diseases caused by similar proteins both within and outside of the nervous system, as well as to diseases involving other types of proteins.