The objectives are to use genome information to understand better the functioning and dysfunctioning of the brain, in order to gain new insight into mental processes, to combat neurological disorders and diseases, and to improve brain repair.

This proposal covers two of the areas funded under this topic:

• LSH-2002-2.1.3-7: Rare monogenic neurological disorders - STREP/CA. This project should focus on the cell biology underlying the neuropathology of rare monogenic neurological disorders (excluding ataxias and rare forms of non-rare diseases such as familial Parkinson's or Alzheimer's disease).
• LSH-2002-2.1.3-8: Genetics and neurobiology of pain - STREP/CA. This project should focus on the basic processes underlying pain (such as neuropathic pain or headache), ranging from genetic to functional studies and response to treatment.